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Forward2024 Endocrinology Grand Rounds | Disorders of Alkaline Phosphatase Affecting Bone Metabolism: Hypophosphatasia and Paget's Disease of the Bone
Hypophosphatasia (HPP) is a rare metabolic bone disease that is not encountered in daily practice, and as a result, can be easily missed. Additionally, HPP has multiple classifications, and varies in its manifestation. Symptoms differ by age, and if left untreated, has a poor life prognosis. In contrast, Paget's disease of the bone is a common metabolic bone disease, just second in line to osteoporosis, however, it too is more common with age and discovery of it can vary, as it can be asymptomatic.
Practicing clinicians need to be kept up to date and abreast of latest advancements in the evaluation and management of metabolic bone disease such as hypophosphatasia and Paget's disease affecting serum alkaphine phosphatase at different spectrums during evaluation of osteoporosis to identify the causes of osteoporosis and offer treatment accordingly.
Target Audience
Faculty and Staff of department of Diabetes, Endocrinology and Metabolism.
Learning Objectives
- Examine the two causes of bone fragility, other than osteoporosis.
- Outline the disease manifestation of these two conditions that are on opposite spectrum of alkaline phosphatase level.
- Recognize both subtle and more severe variants of HPP and Paget's disease, and master their management.
- Discuss possible barriers and biases which may impact patient care (i.e., race, ethnicity, language, gender identity/orientation, age, socioeconomic status, attitudes, feelings, or other characteristics).
Virtual Meeting- Zoom
Azar Khosravi, MD Assistant Professor, Department of Endocrinology and Orthopedic Surgery; Director, Metabolic Bone Program, Cedars-Sinai Medical Center; Assistant Clinic Professor, UCLA Health Sciences
Presenter: Dr. Khosravi has indicated the following relevant financial relationships: Consultant for Kyowa Kirin, and On the Speakers Bureau for Calcilytix.
Planner: Wei Feng, MD has indicated no relevant financial relationships.
The educational content has been peer-reviewed, an attestation on file and no conflicts were noted.
CME Committee/Reviewer no relevant financial relationships: Daneng Li, MD
ACCREDITATION STATEMENT: City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CREDIT DESIGNATION: City of Hope designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The following credit type(s) are being offered for this course:
• AMA PRA Category 1 Credit™ 1.0
The following may apply AMA PRA Category 1 Credit™ for license renewal:
Registered Nurses: Nurses may report up to 1.0 credit hours toward the continuing education requirements for license renewal by their state Board of Registered Nurses (BRN). AMA PRA Category 1 Credit™ may be noted on the license renewal application in lieu of a BRN provider number.
Physician Assistants: The National Commission on Certification of Physicians Assistants states that AMA PRA Category 1 Credit™ accredited courses are acceptable for CME requirements for recertification.
Available Credit
- 1.00 AMA PRA Category 1 Credit™City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
City of Hope designates this 2024 Endocrinology Grand Rounds | Disorders of Alkaline Phosphatase Affecting Bone Metabolism: Hypophosphatasia and Paget's Disease of the Bone for a maximum of 1.00 AMA PRA Category 1 Credit™ requirements. Physicians should claim only the credit commensurate with the extent of their participation in the activity. - 1.00 Attendance