2026 Endocrinology Grand Rounds | Cushing’s Syndrome due to Ectopic Adrenocorticotropic Hormone (ACTH) Secretion: A Clinical Challenge

June 3, 2026

Ectopic Adrenocorticotropic Hormone (ACTH) mediated Cushing's syndrome is a rare and challenging disease. It is difficult to distinguish between ACTH mediated Cushing's from Cushing's disease. Not all clinicians are familiar with the entity, leading to diagnostic delay. 

Given the rarity of ectopic ACTH mediated Cushing's syndrome, clinicians may have limited exposure and clinical experience to this disease. This may lead to the clinician's lack of confidence and ability to take care of patients affected by this rare disease. However, given the increased risk of morbidity and mortality in patients with ectopic ACTH mediated Cushing's syndrome compared to other forms of Cushing's, it is important that clinicians become comfortable in diagnosing and managing ectopic ACTH mediated Cushing's syndrome. This activity will enhance the endocrinologist's ability to care for this unique population alongside their oncology colleagues by discussing how to diagnose ectopic ACTH mediated Cushing's utilizing available diagnostic test and imaging modality and how to best manage ectopic ACTH mediated Cushing's.
 

Target Audience

Physicians, endocrinologists, and all other allied health care professionals interested in the subject matter.

Learning Objectives

  • Identify the most common tumors associated with ectopic adrenocorticotropic hormone (ACTH)-mediated Cushing's syndrome. 
  • Recognize features that distinguish ectopic ACTH-mediated Cushing's syndrome from other forms of Cushing's diseases.
  • Utilize diagnostic tests and imaging modalities to diagnose ectopic ACTH-mediated Cushing's syndrome.
  • Identify the most appropriate treatment plan for patients with ectopic ACTH-mediated Cushing's syndrome.
  • Discuss possible barriers and biases which may impact patient care (i.e., race, ethnicity, language, gender identity/orientation, age, socioeconomic status, attitudes, feelings, or other characteristics).
Activity summary
Available credit: 
  • 1.00 AMA PRA Category 1 Credit™
    City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
    City of Hope designates this 2026 Endocrinology Grand Rounds | Cushing’s Syndrome due to Ectopic Adrenocorticotropic Hormone (ACTH) Secretion: A Clinical Challenge for a maximum of 1.00 AMA PRA Category 1 Credit™ requirements. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  • 1.00 Attendance
Activity opens: 
06/03/2026
Activity expires: 
06/04/2026
Event starts: 
06/03/2026 - 12:30pm PDT
Event ends: 
06/03/2026 - 1:30pm PDT
Add to calendar: 
City of Hope | Virtual

Virtual Meeting- Zoom

Lei Lei, MD  Assistant Clinical Professor, Department of Diabetes, Endocrinology and Metabolism, City of Hope

Presenter: Dr. Lei has indicated that there are no relevant financial relationships with ineligible companies.

Planner: Pooja Manroa, MD has indicated that there are no relevant financial relationships with ineligible companies.

This presentation and/or comments will provide a balanced, non-promotional, and evidence-based approach to all diagnostic, therapeutic and/or research related content. 

CME Committee/Reviewer no relevant financial relationships:  Daneng Li, MD

ACCREDITATION STATEMENT: City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION: City of Hope designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

The following credit type(s) are being offered for this course:

•  AMA PRA Category 1 Credit™  1.0

The following may apply AMA PRA Category 1 Credit™ for license renewal:

Registered Nurses: Nurses may report up to 1.0 credit hours toward the continuing education requirements for license renewal by their state Board of Registered Nurses (BRN). AMA PRA Category 1 Credit™ may be noted on the license renewal application in lieu of a BRN provider number.

Physician Assistants: The National Commission on Certification of Physicians Assistants states that AMA PRA Category 1 Credit™ accredited courses are acceptable for CME requirements for recertification.

Available Credit

  • 1.00 AMA PRA Category 1 Credit™
    City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
    City of Hope designates this 2026 Endocrinology Grand Rounds | Cushing’s Syndrome due to Ectopic Adrenocorticotropic Hormone (ACTH) Secretion: A Clinical Challenge for a maximum of 1.00 AMA PRA Category 1 Credit™ requirements. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
  • 1.00 Attendance
Please login or register to take this activity.