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SATURDAY, SEPTEMBER 21, 2024     

7:00 - 8:00 AM	REGISTRATION / BREAKFAST / EXHIBITS
Session 1: Heterogeneity and Precision Medicine in Diabetes Moderator: Andrew F. Stewart, MD | U.S.
8:00 - 8:25 AM	Heterogeneity of (Pre) Diabetes: Phenotypes Andreas L. Birkenfeld, MD, PhD | Germany
8:25 - 8:50 AM	Heterogeneity of Type 2 Diabetes: Genotypes Miriam S. Udler, MD, PhD | U.S.
8:50 - 9:15 AM	Debate: Precision Medicine in Type 2 Diabetes: We Are Really Close Paul W. Franks, PhD | Sweden
9:15 - 9:40 AM	Debate: Precision Medicine in Type 2 Diabetes: There is More Work to Do David M. Nathan, MD | U.S.
9:40 - 10:00 AM	Panel Discussion
10:00 - 10:15 AM	BREAK/EXHIBITS
Session 2: Obesity and Diabetes: Clinical Moderator: Fouad Kandeel, MD, PhD | U.S.
10:15 - 10:40 AM	Exercise as Medicine for Type 2 Diabetes: Barriers and Opportunities Jane EB Reusch, MD | U.S.
10:40 - 11:05 AM	Select Trial – New Insights into Obesity Treatment Steven E. Kahn, MB, ChB | U.S.
11:05 - 11:20 AM	Panel Discussion
11:20 - 11:30 AM	REFRESHMENT BREAK/EXHIBITS
Session 3: Pros and Cons of GLP-1 Receptor Agonists Moderator: Jane EB Reusch, MD | U.S.
11:30 - 11:55 AM	The Evolving Story of Incretins – Magic Bullet or Hot Air?  David D’Alessio, MD | U.S.
11:55 AM - 12:20 PM	Sarcopenia with GLP-1/Activin  Jose M. Garcia, MD, PhD | U.S.
12:20 - 12:35 PM	Panel Discussion
12:35 - 1:45 PM	LUNCH/EXHIBITS
Session 4: New Insights Offering Potential New Therapies for Diabetes (NON-CME ACCREDITED) Moderator: Gerald I. Shulman, MD, PhD, MACP, MACE, FRCP | U.S.
1:45 - 2:10 PM	Targeting Hepatic Mitochondrial Fat Oxidation to Treat MASLD, MASH and Cardiometabolic Disease Gerald I. Shulman, MD, PhD, MACP, MACE, FRCP | U.S.
2:10 - 2:35 PM	TXNIP Anath Shalev, MD | U.S.
2:35 - 3:00 PM	Debate: Weight Loss in Obesity: Metabolic Surgery is Still King Philip R. Schauer, MD | U.S.
3:00 - 3:25 PM	Debate: Weight Loss in Obesity: It is Time for Metabolic Surgery to Move Over Donna Ryan, MD | U.S.
3:25 - 3:45 PM	Panel Discussion
3:45 - 4:15 PM	REFRESHMENT BREAK/EXHIBITS
Session 5: Mitochondrial Function Moderator: Steven E. Kahn, MB, ChB | U.S.
4:15 - 4:40 PM	Lipid Metabolic Regulators of Steatotic Liver Disease Rotonya M. Carr, MD | U.S.
4:40 - 5:05 PM	Mitochondrial Alterations in Steatotic Liver Diseases Michael Roden, MD | Germany
5:05 - 5:30 PM	Citrin Deficiency as a Window into ChREBP, FGF21 and the Desire for Sweets Charles Brenner, PhD | U.S.
5:30 - 5:50 PM	Panel Discussion
6:00 - 7:00 PM	Poster Session
7:00 - 8:30 PM	SYMPOSIUM DINNER

SUNDAY, SEPTEMBER 22, 2024

7:00 - 8:00 AM	REGISTRATION / BREAKFAST / EXHIBITS
Session 1: Obesity: Advances in Basic and Applied Biology Moderator: Debbie C. Thurmond, PhD | U.S.
8:00 - 8:25 AM	Regulation of Fatty Acid Hydroxy Fatty Acids: Implications for Type 1 and Type 2 Diabetes and Monogenic Diabetes Barbara B. Kahn, MD | U.S.
8:25 - 8:50 AM	Out for Blood: Biochemical Profiling of Human Populations for Cardiometabolic Biomarker and Pathway Discovery Robert E. Gerszten, MD | U.S.
8:50 - 9:15 AM	Time Restricted Eating – Clinical Perspective Lisa Chow, MD, MS | U.S.
9:15 - 9:35 AM	Panel Discussion
9:35 - 9:50 AM	BREAK / EXHIBITS
Session 2: Diabetes in Youth and Diabetes Complications Moderator: Carmella Evans-Molina, MD, PhD | U.S.
9:50 - 10:15 AM	Youth-onset Type 2 Diabetes: Amplified Pathology due to Hormonal, Genetic, Environmental and Societal Influences Tamara S. Hannon, MD, MS | U.S.
10:15 - 10:40 AM	Treatment of Type 2 Diabetes in Youth: Need for Aggressive Use of Non-approved Glucose Lowering Medications Megan Moriarty Kelsey, MD, MS | U.S.
10:40 - 11:05 AM	Is Bariatric Surgery Still Appropriate for Youth? Justin Ryder, PhD | U.S.
11:05 - 11:30 AM	What has the Proteome Taught us About Diabetes Complications? Petter Björnstad, MD | U.S.
11:30 - 11:50 AM	Panel Discussion
11:50 AM - 1:15 PM	LUNCH / EXHIBITS
Rachmiel Levine Award Lecture (NON-CME ACCREDITED) Moderator: David M. Harlan, MD | U.S.
1:15 - 1:55 PM	Determinants of Islet Autoimmunity and Implications for Prevention of Type 1 Diabetes Anette-Gabriele Ziegler, MD | Germany
1:55 - 2:00 PM	Q&A
2:00 - 2:10 PM	BREAK / EXHIBITS
California Institute for Regenerative Medicine (CIRM) Talk  (NON-CME ACCREDITED)
2:10 - 2:40 PM	Advancing Cell and Gene Therapies in California and Beyond Ross M. Okamura, PhD | U.S.
2:40 - 2:50 PM	BREAK / EXHIBITS
Session 3: TRAINEE ORAL PRESENTATIONS (NON-CME ACCREDITED) Moderator: Jane EB Reusch, MD | U.S.
2:50 - 3:05 PM	Beta Cell-specific PAK1 Enrichment Ameliorates Diet-induced Glucose Intolerance by Promoting Insulin Biogenesis and Minimizing Beta Cell Apoptosis Miwon Ahn, PhD | U.S.
3:05 - 3:20 PM	DOC2b Prevents Cytokine-induced CXCL10 Expression via Attenuating IKKb- NF-kB p65 and STAT-1 Signaling in Human Islets  Diti Chatterjee Bhowmick, PhD | U.S.
3:20 - 3:35 PM	Extracellular Vesicles Produced by Proinflammatory Cytokine-treated Human Ductal Cells Increase HLA Class I Expression in EndoC-βH1 Beta Cells Neslihan Erdem | U.S.
3:35 - 3:50 PM	Human Pancreatic α-cell Heterogeneity and Trajectory Inference Analyses of Human Islets Uncover SMOC1 as a β-cell Dedifferentiation Gene Randy Kang | U.S.
3:50 - 4:05 PM	Enhancing β-cell Survival and Modulating Immune Response in Type 1 Diabetes Through Harmine and Exendin-4 Combination Therapy Geming Lu, PhD | U.S.
4:05 - 4:20 PM	REFRESHMENT BREAK / EXHIBITS
Session 4: Beta Cell Acting Agents for Cell Expansion and/or Improved Function Moderator: Jay Tinklepaugh, PhD (BreakthroughT1D) | U.S.
4:20 - 4:45 PM	Dyrk1A Inhibitors (Harmine Analogs) Adolfo Garcia-Ocaña, PhD | U.S.
4:45 - 5:10 PM	Denosumab, an Osteoporosis Drug, Potential to Treat Diabetes Rupangi Vasavada, PhD | U.S.
5:10 - 5:35 PM	Gastrin Fouad Kandeel, MD, PhD | U.S.
5:35 - 5:55 PM	Panel Discussion

MONDAY, SEPTEMBER 23, 2024

7:00 - 8:00 AM	REGISTRATION / BREAKFAST / EXHIBITS
Session 1: Islet Transplant vs. Stem Cells Moderator: Fouad Kandeel, MD, PhD
8:00 - 8:25 AM	Bench Marking for Islet Transplantation Alessandro Parente, MD, PhD | UK
8:25 - 8:50 AM	Approaches for Extrahepatic Site for Cell Transplant Hirotake Komatsu, MD, PhD | U.S.
8:50 - 9:15 AM	Encapsulation as a Means for Immune Protection Alice A. Tomei, PhD | U.S.
9:15 - 9:35 AM	Panel Discussion
9:35 - 9:50 AM	BREAK / EXHIBITS
Session 2: Diabetes Moonshots Moderators: Steven E. Kahn, MB, ChB | U.S.
9:50 - 10:15 AM	Prevention of Type 1 Diabetes: What is the Evidence? Carmella Evans-Molina, MD, PhD | U.S
10:15 - 10:40 AM	Debate: Cell Replacement Therapies as the Goal for Treating Type 1 Diabetes Michael R. Rickels, MD, MS | U.S
10:40 - 11:05 AM	Debate: Remarkable Advances in Closed Loop Therapies Largely Obviate the Need for  Islet Therapy Anne Peters, MD | U.S.
11:05 - 11:30 AM	Patient Perspectives on Islet Transplantation, Insulin Pump, and Closed Loop Therapies City of Hope Patients – Richard Holbrook; Kelly Person, CPA, MBA; Susan Weinberg, MA; and  Angela William
11:30 - 11:50 AM	Panel Discussion
11:50 AM - 1:00 PM	LUNCH / EXHIBITS
Arthur Riggs Award Lecture (NON-CME ACCREDITED) Moderator: David M. Harlan, MD
1:00 - 1:40 PM	Metabolic Regulation of Insulin Secretion in Health and Disease (Zoom Session) Frances Ashcroft, PhD | UK
1:40 - 1 :45 PM	Q&A
1:45 - 1:55 PM	BREAK / EXHIBITS
Session 3: Hypoimmunogenic Islets and Islet-like Structures [Part 1] (NON-CME ACCREDITED) Moderators: David M. Harlan, MD | U.S.
1:55 - 2:20 PM	Peptide-MHC-based Nanomedicines for the Treatment of Autoimmune Inflammation: Mechanisms and Applications Pere Santamaria, MD, PhD | Canada
2:20 - 2:25 PM	Q&A
2:25 - 2:35 PM	BREAK / EXHIBITS
Session 4: TRAINEE ORAL PRESENTATIONS (NON-CME ACCREDITED) Moderator: Jane EB Reusch, MD | U.S.
2:35 - 2:50 PM	BET Signaling and FXR Signaling Orchestrate to Protect β Cells   Fritz Cayabyab | U.S.
2:50 - 3:05 PM	Modeling the Effects of Early Hyperinsulinemia due to the R1420H SUR1 Mutation using Isogenic iPSC-derived Pancreatic Islets  Anup Nair, PhD | U.S
3:05 - 3:20 PM	Novel Metabolomic Profiles of Elevated Blood Pressure Remission Five Years after Bariatric Surgery among Adolescents Shudi Pan | U.S.
3:20 - 3:35 PM	Deletion of Mitogen-inducible Gene-6 (Mig6) in the Liver Alters Glucose Homeostasis and Delays Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) Progression  Marissa Saenz, DVM | U.S.
3:35 - 3:50 PM	Alteration of Bile Acid Conjugation by Gut Microbiota Mediates VSG-induced Fat Loss Mingfeng Zhang, PhD | U.S
3:50 - 4:05 PM	REFRESHMENT BREAK / EXHIBITS

Session 5: Hypoimmunogenic Islets and Islet-like Structures [Part 2] (NON-CME ACCREDITED) Moderators: David M. Harlan, MD | U.S.
4:05 - 4:30 PM	Over Expressing CD 47 in Beta Cells and Immune Evasion Sonja Schrepfer, MD, PhD | U.S.
4:30 - 4:55 PM	Functional Selection, Mass Production and PD-L1-based Immune-evasion in Human  Islet-like Organoids Eiji Yoshihara, PhD | U.S.
4:55 - 5:20 PM	Stem Cell-based Therapies for Diabetes Matthias Hebrok, PhD | German
5:20 - 5:40 PM	Panel Discussion

TUESDAY, SEPTEMBER 24, 2024    

7:00 - 8:00 AM	REGISTRATION / BREAKFAST / EXHIBITS
Session 1: What is New in Diabetic Complications - Mechanisms, Therapies and Beyond [Part 1] Moderator: Rama Natarajan, PhD | U.S.
8:00 - 8:25 AM	RAGE/DIAPH1 Axis: Understanding Mechanisms of Obesity and Diabetes Complications & New Therapeutic Opportunities Ann Marie Schmidt, MD | U.S.
8:25 - 8:50 AM	Diabetic Retinopathy: Stem Cells and New Insights Maria B. Grant, MD | U.S.
8:50 - 9:05 AM	Panel Discussion
9:05 - 9:20 AM	BREAK / EXHIBITS
Session 2: Cancer and Diabesity Moderator: Charles Brenner, PhD | U.S.
9:20 - 9:45 AM	Investigating the Link Between Metabolic Health, Obesity, and Cancer Risk in Diverse Los Angeles Women Christina Vidal, PhD | U.S.
9:45 - 10:10 AM	A New Metabolic Approach to Cancer-related Fatigue: Implications for Inactivity in Obesity and Diabetes Rachel Perry, PhD | U.S
10:10 - 10:35 AM	Association Between Diabetes and Carcinogenesis Sarah Shuck, PhD | U.S
10:35 - 11:00 AM	Early Onset Colon Cancer and Obesity Emina Huang, MD, MBA | U.S
11:00 - 11:20 AM	Panel Discussion
11:20 - 11:50 AM	BREAK / EXHIBITS
Session 3: What is New in Diabetic Complications - Mechanisms, Therapies and Beyond [Part 2] (NON-CME ACCREDITED) Moderator: Rama Natarajan, PhD | U.S.
11:50 - 12:15 PM	Exploring Mitochondrial Metabolism to Improve Cardiometabolic Health Leigh Goedeke, PhD | U.S.
12:15 - 12:40 PM	Precision Medicine for Diabetic Nephropathy: Lessons Learned from Emerging Omics Profiling Kumar Sharma, MD | U.S.
12:40 - 12:55 PM	Panel Discussion
12:55 PM	MEETING ADJOURNS - Lunch (Boxed - to go)